Controlled release of matrix metalloproteinase 1 with or without skeletal myoblasts transplantation improves cardiac function of rat hearts with chronic myocardial infarction.

Xue Lin, Keiichi Tammbara, Michael Fu, Masaya Yamamoto, Goditha U. Premaratne, Yutaka Sakakibara, Akira Marui, Tadashi Ikeda, Masashi Komeda, Yasuhiko Tabata

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Skeletal myoblast transplantation has been applied clinically for severe ischemic cardiomyopathy. Matrix metalloproteinase 1 (MMP-1) reduces fibrosis and prevents the progress of heart failure. We hypothesized that MMP-1 administration to the infarct area enhances the efficacy of skeletal myoblast transplantation. The controlled release of MMP-1 improved cardiac functions of rats with chronic myocardiac infarction with or without transplantation of skeletal myoblasts. Improvement in cardiac function and small fibrotic area inside the infarcted area were observed compared with those of myoblast transplantation. In conclusion, controlled release of MMP-1 was effective in cardioprotection in postmyocardial infarction although the combination with cell transplantation showed the similar effect.

Original languageEnglish
Pages (from-to)2699-2706
Number of pages8
JournalTissue engineering. Part A
Volume15
Issue number9
DOIs
Publication statusPublished - 2009 Sep

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

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