Several mathematical models on intermittent androgen suppression (IAS) therapy for prostate cancer are classified into hybrid PDE-ODE system with structural instability. The purpose of this paper is to give a unified strategy to prove the controllability of themathematicalmodels on the IAS therapy. For this aim, we prove that (1) a generalized hybrid PDE-ODE system is controllable for any initial data and (2) the result given by (1) is applicable to the mathematical models on the IAS therapy. Finally, we conclude that the mathematical models on the IAS therapy for prostate cancer are controllable for any initial data.
- Comparison principle
- Indirectly controlled parameter
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