Control-released hepatocyte growth factor enhances the efficacy of cardiomyocyte transplantation by increasing the survival rate of the donor cells

K. Tambara, G. U. Premaratne, Y. Sakakibara, H. Nakajima, N. Kanemitsu, M. Yamamoto, M. Ozeki, Y. Tabata, M. Komeda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effect of simultaneous administration of control-released HGF on the efficacy of CM Tx in a rat myocardial infarction (MI) model was investigated. HGF-impregnated gelatin hydrogel sheets, which enable HGF to be released in situ over 2 weeks was developed. MI was created by ligating the left coronary artery in Lewis rats. The rats that developed moderate-sized MI were divided into GroupI, II and III. Transplanted CMs were found over the whole MI area in Group I, while few donor CMs were detected in the center of the scar in Group II. The result shows that simultaneous application of HGF-impregnated gelatin hydrogel sheets may enhance the efficacy of CM Tx by improving the survival rate of donor CMs in chronic MI.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages724
Number of pages1
Publication statusPublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 2004 May 172004 May 21

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period04/5/1704/5/21

ASJC Scopus subject areas

  • Engineering(all)

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