Control of wall thickness of blood vessel biomodel made of poly (vinyl alcohol) hydrogel by a three-dimensional-rotating spin dip-coating method

Hiroyuki Kosukegawa, Chihaya Kiyomitsu, Makoto Ohta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

To control the thickness of a PVA-H biomodel of human arteries and veins (150 to 800 μm in thickness), a threedimensional-rotating spin dip-coating apparatus was fabricated. A straight aluminum cylinder (Ra = 0.16 μm) was employed as substrate. Spin dip-coating was carried out in a cooling chamber at 10°C for 1 hour, and then the substrate was quenched at -30°C for gelation of PVA. The thickness of the deposited PVA-H was measured by using a confocal laser displacement meter. Under the experimental conditions employed, PVA-H with a thickness over 30 μm was obtained. The thickness linearly increased with repeated dippings. The thickness of PVA-H depends on the dipping withdrawal speed, the viscosity of the PVA solution, and the diameter of the substrate. Furthermore, the thickness of PVA-H was found to be almost the same when the viscosity of the PVA solution was constant, regardless of the concentrations of PVA. These results indicate that a tubeshaped PVA-H biomodel with desired thickness and physical properties can be obtained by using a spin dip-coating technique and that PVA-H can mimic the wall thickness of various arteries and veins.

Original languageEnglish
Title of host publicationBiomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages221-228
Number of pages8
ISBN (Print)9780791854884
DOIs
Publication statusPublished - 2011
EventASME 2011 International Mechanical Engineering Congress and Exposition, IMECE 2011 - Denver, CO, United States
Duration: 2011 Nov 112011 Nov 17

Publication series

NameASME 2011 International Mechanical Engineering Congress and Exposition, IMECE 2011
Volume2

Other

OtherASME 2011 International Mechanical Engineering Congress and Exposition, IMECE 2011
Country/TerritoryUnited States
CityDenver, CO
Period11/11/1111/11/17

Keywords

  • Biomodel
  • Blood vessel
  • Dip-coating method
  • PVA hydrogel
  • Wall thickness

ASJC Scopus subject areas

  • Mechanical Engineering

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