Control of MAP kinase signaling to the nucleus

Kunio Kondoh, Satoru Torii, Eisuke Nishida

    Research output: Contribution to journalShort surveypeer-review

    78 Citations (Scopus)


    MAP kinase (MAPK) signaling is among central signaling pathways that regulate cell proliferation, cell differentiation and apoptosis. As MAPK should transmit extracellular signals to proper regions or compartments in cells, controlling subcellular localization of MAPK is important for regulating fidelity and specificity of MAPK signaling. The ERK1/2-type of MAPK is the best characterized member of the MAPK family. In response to extracellular stimulus, ERK1/2 translocates from the cytoplasm to the nucleus by passing through the nuclear pore by several independent mechanisms. Sef (similar expression to fgf genes), a transmembrane protein, has been shown to be a regulator of subcellular distribution of ERK1/2. Sef binds to activated MEK1/2, the specific activator of ERK1/2, and tethers the activated MEK1/2/activated ERK1/2 complex to the Golgi apparatus and the plasma membrane. Thus, Sef blocks ERK1/2 signaling to the nucleus and allows signaling to the cytoplasm. Here we review recent findings on spatial regulation of MAPK, especially on nucleocytoplasmic trafficking of ERK1/2.

    Original languageEnglish
    Pages (from-to)86-91
    Number of pages6
    Issue number2
    Publication statusPublished - 2005 Jul 1

    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)


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