Control of cell adhesion and functions using self-organized honey Comb-patterned polymer films

Masaru Tanaka, Akinori Tsuruma, Sadaaki Yamamoto, Masatsugu Shimomura

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The design of nano-and microstructures based on self-organization is a key area of research in the search for new biomaterials and biodevices,and such structures have a variety of potential applications in tissue engineering scaffolds and medical implants.3D scaffolds of appropriate pore size and porosities and with interconnected pores are required to facilitate cell adhesion, proliferation,differentiation,and eventual tissue regeneration in a natural manner.We have reported the honeycomb-patterned polymer film with highly regular pores that is formed by self-organization.The honeycomb films exerted a strong influence on cell morphology, proliferation,cytoskeleton, focal adhesion,and ECM production profiles.Our studies demonstrated that the neural stem / progenitor cells morphology,proliferation,and differentiation are controlled by the pore size of the honeycomb film.It is expected that the honeycomb films will have great potentials as biomaterials for tissue regeneration in a growth factor free proliferation process of stem cells.

    Original languageEnglish
    Title of host publicationBIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices
    Pages390-393
    Number of pages4
    Publication statusPublished - 2009 Jul 21
    Event2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 - Porto, Portugal
    Duration: 2009 Jan 142009 Jan 17

    Publication series

    NameBIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices

    Other

    Other2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009
    CountryPortugal
    CityPorto
    Period09/1/1409/1/17

    Keywords

    • Cell adhesion
    • Honeycomb
    • Scaffold
    • Self-organization
    • Stem cell
    • Tissue engineering

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Electrical and Electronic Engineering

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  • Cite this

    Tanaka, M., Tsuruma, A., Yamamoto, S., & Shimomura, M. (2009). Control of cell adhesion and functions using self-organized honey Comb-patterned polymer films. In BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices (pp. 390-393). (BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices).