The dissolution behavior of Ag-containing hydroxyapatite (HA) powders and their sintered comparts in a Tris buffer solution (TBS) with a pH value of 7.4 was investigated. The Ag-containing calcium phosphate powders were prepared by a precipitation method using aqueous solutions. The (Ca+Ag)/P and Ag/(Ca+Ag) atomic ratios in the solutions were set to 1.33 and 1.67 and 0 and 0.10, respectively. The precipitated powders were sintered at 1373 K for 1 d. β-tricalcium phosphate (TCP) and HA were the main phases of the sintered compacts at (Ca+Ag)/P ratios of 1.33 and 1.67, respectively. Metallic Ag coexisted with HA, and Ag was incorporated into the β-TCP matrix. Ag ion release was observed in both the as-precipitated powders and the sintered compacts in the TBS. The amount of Ag ion release from the sintered compacts of the β-TCP matrix was higher than that from the sintered compacts with the HA matrix and metallic Ag particles. The formation of AgCl was confirmed during the immersion of both the as-precipitated powders and the sintered compacts.