Contribution of interferon-β to the immune activation induced by double-stranded DNA

Hidekazu Shirota, Ken J. Ishii, Hiroki Takakuwa, Dennis M. Klinman

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Introducing double-stranded DNA (dsDNA) into the cytoplasm of macrophages and dendritic cells triggers the activation of these professional antigen-presenting cells (APCs). This process is characterized by the up-regulation of costimulatory molecules and the production of various cytokines, chemokines, and antibacterial/viral factors. Current findings indicate that interferon-β (IFN-β) plays a key role in the stimulatory cascade triggered by dsDNA. Both immune and non-immune cells respond to intracytoplasmic dsDNA by up-regulating IFN-β) expression, a process that reduces host susceptibility to infection. The immune activation induced by dsDNA is independent of MyD88, TRIF and DNA-PKcs, indicating that a Toll-like receptor-independent mechanism underlies the cellular activation mediated by intracytoplasmic dsDNA.

Original languageEnglish
Pages (from-to)302-310
Number of pages9
JournalImmunology
Volume118
Issue number3
DOIs
Publication statusPublished - 2006 Jul 1
Externally publishedYes

Keywords

  • DNA
  • Host protection
  • Toll-like receptor
  • Type 1 IFNs

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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