Contrast-enhanced high-frequency ultrasound imaging of liver metastases in preclinical models

Rui Chen, Noriko Tomita, Taisuke Baba, Fuki Oosawal, Yukiko Watanabe, Sachiko Horie, Shiro Mori, Manabu Fukumoto, Tetsuya Kodama

Research output: Contribution to journalConference articlepeer-review


Preclinical mouse models are essential to the study of liver metastasis, yet their utility has been limited by difficulty in tracking the progression of metastases through time. In this study, liver metastases were identified by in vivo bioluminescence system and a high-frequency ultrasound system with nanobubbles. Tumor grows and vessel densities were calculated. Liver metastases were observed on the second days after inoculation and confirmed by the HE staining. Vessels density in the liver metastasis group was increased compared to the control group. This study show that three-dimensional high-frequency ultrasound imaging combined with nanobubbles may be suited for early detection, quantitative assessment of metastatic progression in liver metastasis models.

Original languageEnglish
Article number4803505
Pages (from-to)1742-1744
Number of pages3
JournalProceedings - IEEE Ultrasonics Symposium
Publication statusPublished - 2008 Dec 1
Event2008 IEEE International Ultrasonics Symposium, IUS 2008 - Beijing, China
Duration: 2008 Nov 22008 Nov 5


  • High-frequency ultrasound
  • In vivo bioluminescence system
  • Liver metastasis

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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