Contraction of cross-linked actomyosin bundles

Natsuhiko Yoshinaga, Philippe Marcq

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Cross-linked actomyosin bundles retract when severed in vivo by laser ablation, or when isolated from the cell and micromanipulated in vitro in the presence of ATP. We identify the timescale for contraction as a viscoelastic time τ, where the viscosity is due to (internal) protein friction. We obtain an estimate of the order of magnitude of the contraction time τ ≈ 10-100 s, consistent with available experimental data for circumferential microfilament bundles and stress fibers. Our results are supported by an exactly solvable, hydrodynamic model of a retracting bundle as a cylinder of isotropic, active matter, from which the order of magnitude of the active stress is estimated.

Original languageEnglish
Article number046004
JournalPhysical Biology
Volume9
Issue number4
DOIs
Publication statusPublished - 2012 Aug

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology
  • Cell Biology

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