TY - JOUR
T1 - Continuous hydrothermal synthesis of 3,4-dihydroxyhydrocinnamic acid-modified magnetite nanoparticles with stealth-functionality against immunological response
AU - Togashi, Takanari
AU - Takami, Seiichi
AU - Kawakami, Kazuyoshi
AU - Yamamoto, Hideki
AU - Naka, Takashi
AU - Sato, Koichi
AU - Abe, Keietsu
AU - Adschiri, Tadafumi
PY - 2012/5/14
Y1 - 2012/5/14
N2 - In our study, water dispersible magnetite (Fe 3O 4) nanoparticles were continuously synthesized in water under high temperature and pressure in the presence of 3,4-dihydroxyhydrocinnamic acid (DHCA) by using a tubular flow reactor. The prepared Fe 3O 4 nanoparticles were well dispersed in water because the surfaces of the nanoparticles were fully covered by DHCA molecules and the -COOH groups in the DHCA molecules were exposed to the surrounding water. Cytokines such as IL-12 and TNF-α were not produced from the dendritic cells of mice by co-incubation with our synthesized Fe 3O 4. This indicates that the synthesized Fe 3O 4 had no immune stimulating property for the dendritic cells of the mouse. Therefore, our synthesized Fe 3O 4 nanoparticles are suitable for biological applications such as magnetic resonance imaging contrast agents and carriers for drug and gene delivery, and in areas such as hyperthermia therapy for cancer, biosensors, and tissue engineering.
AB - In our study, water dispersible magnetite (Fe 3O 4) nanoparticles were continuously synthesized in water under high temperature and pressure in the presence of 3,4-dihydroxyhydrocinnamic acid (DHCA) by using a tubular flow reactor. The prepared Fe 3O 4 nanoparticles were well dispersed in water because the surfaces of the nanoparticles were fully covered by DHCA molecules and the -COOH groups in the DHCA molecules were exposed to the surrounding water. Cytokines such as IL-12 and TNF-α were not produced from the dendritic cells of mice by co-incubation with our synthesized Fe 3O 4. This indicates that the synthesized Fe 3O 4 had no immune stimulating property for the dendritic cells of the mouse. Therefore, our synthesized Fe 3O 4 nanoparticles are suitable for biological applications such as magnetic resonance imaging contrast agents and carriers for drug and gene delivery, and in areas such as hyperthermia therapy for cancer, biosensors, and tissue engineering.
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U2 - 10.1039/c2jm30325f
DO - 10.1039/c2jm30325f
M3 - Article
AN - SCOPUS:84859851541
VL - 22
SP - 9041
EP - 9045
JO - Journal of Materials Chemistry
JF - Journal of Materials Chemistry
SN - 0959-9428
IS - 18
ER -