Continuous hydrothermal synthesis of 3,4-dihydroxyhydrocinnamic acid-modified magnetite nanoparticles with stealth-functionality against immunological response

Takanari Togashi, Seiichi Takami, Kazuyoshi Kawakami, Hideki Yamamoto, Takashi Naka, Koichi Sato, Keietsu Abe, Tadafumi Adschiri

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

In our study, water dispersible magnetite (Fe 3O 4) nanoparticles were continuously synthesized in water under high temperature and pressure in the presence of 3,4-dihydroxyhydrocinnamic acid (DHCA) by using a tubular flow reactor. The prepared Fe 3O 4 nanoparticles were well dispersed in water because the surfaces of the nanoparticles were fully covered by DHCA molecules and the -COOH groups in the DHCA molecules were exposed to the surrounding water. Cytokines such as IL-12 and TNF-α were not produced from the dendritic cells of mice by co-incubation with our synthesized Fe 3O 4. This indicates that the synthesized Fe 3O 4 had no immune stimulating property for the dendritic cells of the mouse. Therefore, our synthesized Fe 3O 4 nanoparticles are suitable for biological applications such as magnetic resonance imaging contrast agents and carriers for drug and gene delivery, and in areas such as hyperthermia therapy for cancer, biosensors, and tissue engineering.

Original languageEnglish
Pages (from-to)9041-9045
Number of pages5
JournalJournal of Materials Chemistry
Volume22
Issue number18
DOIs
Publication statusPublished - 2012 May 14

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Continuous hydrothermal synthesis of 3,4-dihydroxyhydrocinnamic acid-modified magnetite nanoparticles with stealth-functionality against immunological response'. Together they form a unique fingerprint.

Cite this