TY - JOUR
T1 - Content of delusional thoughts in Alzheimer's disease and assessment of content-specific brain dysfunctions with BEHAVE-AD-FW and SPECT
AU - Nakatsuka, Masahiro
AU - Meguro, Kenichi
AU - Tsuboi, Hiroshi
AU - Nakamura, Kei
AU - Akanuma, Kyoko
AU - Yamaguchi, Satoshi
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/6
Y1 - 2013/6
N2 - Background: A consensus on the brain dysfunction(s) underlying the delusions of Alzheimer's Dementia (AD) remains to be achieved. The aim of the present study was to test the hypothesis that content-based categorization of delusional ideas manifests as dysfunction of category-specific brain regions. Methods: Fifty-nine consecutive first-visit AD outpatients underwent Single Photon Emission Computed Tomography (SPECT), Mini-Mental State Examination, and Behavioral Pathology in Alzheimer's Disease Frequency-Weighted Severity scale (BEHAVE-AD-FW) to assess cerebral blood flow (CBF), cognitive function, and delusion, respectively. SPECT images were analyzed by SPM5. Results: CBF decreased at the temporal poles and right inferior temporal gyrus in delusion of theft, at the temporal poles in suspiciousness/paranoia, at the right parahippocampal gyrus and insula in abandonment, and at the right amygdala in Residence is not home. Conclusions: Our findings offer a perspective on the discrete categories of the pathological thoughts of AD patients that have previously been lumped together as delusions. Dysfunction of the temporal poles may be associated with a socioemotional deterioration that may include pathological suspiciousness. Delusion of theft may be a manifestation of socioemotional deterioration and poor insight. Emotional factors may be essential for delusions of abandonment and not home.
AB - Background: A consensus on the brain dysfunction(s) underlying the delusions of Alzheimer's Dementia (AD) remains to be achieved. The aim of the present study was to test the hypothesis that content-based categorization of delusional ideas manifests as dysfunction of category-specific brain regions. Methods: Fifty-nine consecutive first-visit AD outpatients underwent Single Photon Emission Computed Tomography (SPECT), Mini-Mental State Examination, and Behavioral Pathology in Alzheimer's Disease Frequency-Weighted Severity scale (BEHAVE-AD-FW) to assess cerebral blood flow (CBF), cognitive function, and delusion, respectively. SPECT images were analyzed by SPM5. Results: CBF decreased at the temporal poles and right inferior temporal gyrus in delusion of theft, at the temporal poles in suspiciousness/paranoia, at the right parahippocampal gyrus and insula in abandonment, and at the right amygdala in Residence is not home. Conclusions: Our findings offer a perspective on the discrete categories of the pathological thoughts of AD patients that have previously been lumped together as delusions. Dysfunction of the temporal poles may be associated with a socioemotional deterioration that may include pathological suspiciousness. Delusion of theft may be a manifestation of socioemotional deterioration and poor insight. Emotional factors may be essential for delusions of abandonment and not home.
KW - behavior
KW - dementia
KW - heterogeneity
KW - psychosis
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U2 - 10.1017/S1041610213000094
DO - 10.1017/S1041610213000094
M3 - Article
C2 - 23433495
AN - SCOPUS:84876739376
VL - 25
SP - 939
EP - 948
JO - International Psychogeriatrics
JF - International Psychogeriatrics
SN - 1041-6102
IS - 6
ER -