Contamination of 2-deoxy-2-[18F]fluoro-d-mannose in the 2-deoxy-2-[18F]fluoro-d-glucose preparations synthesized from [18F]acetyl hypofluorite and [18F]F2

Kiichi Ishiwata, Tatsuo Ido, Hiroaki Nakanishi, Ren Iwata

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    15 Citations (Scopus)

    Abstract

    The presence of 2-deoxy-2-[18F]fluoro-d-mannose ([18F]FDM) in 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) prepared by the reaction of 3,4,6-tri-O-acetyl-d-glucal (TAG) with [18F]acetyl hypofluorite ([18F]CH3COOF) or [18F]F2 was quantified by radio HPLC analysis of reacetylated [18F]FDG. The solvent effects on the stereoselectivity of the reaction of TAG with [18F]CH3COOF were examined in six kinds of solvent. Reaction of TAG with [18F]CH3COOF in Freon-11 results in the least contamination of [18F]FDM (4-5%). The presence of [18F]FDM in the [18F]FDG prepared from TAG with [18F]F2 was also indicated, but by careful chromatographic separation of hexopyranosyl difluorides the amount was reduced to nearly that resulting from the [18F]CH3COOF method.

    Original languageEnglish
    Pages (from-to)463-466
    Number of pages4
    JournalInternational Journal of Radiation Applications and Instrumentation. Part
    Volume38
    Issue number6
    DOIs
    Publication statusPublished - 1987

    ASJC Scopus subject areas

    • Radiation
    • Engineering(all)

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