Construction of the AG-ring unit of pinnatoxin A via intramolecular alkylation and aza-Wittig reaction

Jin Wang, Satoshi Sakamoto, Kei Kamada, Aiko Nitta, Takeshi Noda, Hiroki Oguri, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

An efficient synthetic route to the spirally fused AG-ring model of pinnatoxin A has been devised using the intramolecular cyclization of epoxy nitrile followed by an aza-Wittig reaction to form a seven-membered cyclic imine.

Original languageEnglish
Pages (from-to)891-893
Number of pages3
JournalSynlett
Issue number6
Publication statusPublished - 2003 May 26

Keywords

  • Alkylation
  • Aza-Wittig reaction
  • Cyclic imine
  • Pinnatoxi A
  • Spiro ring

ASJC Scopus subject areas

  • Organic Chemistry

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