Construction of key building blocks towards the synthesis of cortistatins

Satrajit Indu, Rahul D. Telore, Krishna P. Kaliappan

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

This work reports the construction of key building blocks towards the synthesis of cortistatins; a family of steroidal alkaloids. Cortistatin A, being a primary target due to its superior biological properties over other congeners, has been prepared by two different synthetic routes. Synthesis of the precursor to the heavily substituted A-ring starting from d-glucose and construction of the DE-ring junction employing a Hajos-Parrish ketone as a chiral pool have been demonstrated. Efforts are underway to assemble these key fragments and build towards the total synthesis of cortistatin A.

Original languageEnglish
Pages (from-to)2432-2446
Number of pages15
JournalOrganic and Biomolecular Chemistry
Volume18
Issue number13
DOIs
Publication statusPublished - 2020 Apr 7
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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