Construction of fused oxonene ring and reproduction of conformational behavior shown by ring F of ciguatoxin

Masayuki Inoue, Makoto Sasaki, Kazuo Tachibana

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

trans-Fused 6-9-6 tricyclic ether 2 was synthesized and conformational alternation of the oxonene ring was reproduced as was observed for that in the ciguatoxin molecule (ring F). SmI2-promoted intramolecular Reformatsky reaction of O-linked bicyclic compound 4 features the construction of an oxonane ring in the present synthesis.

Original languageEnglish
Pages (from-to)1611-1614
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number9
DOIs
Publication statusPublished - 1997 Mar 3
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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