Construction of fluorinated chiral center

Research output: Contribution to journalReview articlepeer-review

Abstract

Fluorinated compounds have drawn the attention of medicinal chemists because of their potential metabolic tolerance and modulation of drug efficacy. Thus stereo- and enantioselective construction of fluorinated carbon center is an important issue. In spite of remarkable progress in the last decade, the first effective method of catalytic enantioselective fluorination by nucleophilic fluorine reagent has been reported in this year. In this article, construction of fluorinated chiral center is reviewed being categolized into three classes.

Original languageEnglish
Pages (from-to)962-963
Number of pages2
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume68
Issue number9
DOIs
Publication statusPublished - 2010 Sep
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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