Construction of Dibenzazocine Skeleton by Regiocontrolled Ring-Expansion Reaction of Cyclic Oxime with DIBAL-H: Facile Synthesis of 17β-Hydroxy- steroid Dehydrogenase Type 3 Inhibitor

Hidetsura Cho, Yusuke Iwama, Kentaro Okano, Hidetoshi Tokuyama

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Synthetic studies on a 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor are described. The unsymmetrical dibenzazocine skeleton was constructed by a regiocontrolled ring-expansion reaction of a cyclic oxime with DIBAL-H.

Original languageEnglish
Pages (from-to)813-816
Number of pages4
JournalSynlett
Volume24
Issue number7
DOIs
Publication statusPublished - 2013 Mar 15

Keywords

  • hetero-cycles
  • rearrangement
  • reduction
  • regioselectivity
  • ring expansion

ASJC Scopus subject areas

  • Organic Chemistry

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