Conjugating pyrene onto PNA-based fluorescent probes for improved detection selectivity toward double-stranded siRNA

Yusuke Sato, Yuki Takahashi, Takaaki Tanabe, Seiichi Nishizawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We report on the design of new siRNA-binding fluorescent probes with the improved detection selectivity toward intact double-stranded siRNAs over single-stranded forms by the conjugation of pyrene unit into thiazole orange base surrogate-carrying peptide nucleic acid (PNA) that can simultaneously recognize the 3′-overhang and double-stranded sequences of target siRNAs.

Original languageEnglish
Pages (from-to)4009-4013
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume18
Issue number21
DOIs
Publication statusPublished - 2020 Jun 7

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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