Conization by Harmonic Scalpel for cervical intraepithelial neoplasia: A clinicopathological study

Jun Ichi Akahira, Ryo Konno, Takuya Moriya, Hiromitsu Yamakawa, Tsukasa Igarashi, Kiyoshi Ito, Shinji Sato, Akira Yajima

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The Harmonic Scalpel (HS) is a new surgical tool that cuts and coagulates by converting electrical energy into ultrasonic mechanical vibrations. The purpose of our study was to compare HS conization and the loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN) with respect to both clinical and pathological features. Fifty-one consecutive women conservatively treated (29 with LEEP and 22 with HS conization) for CIN III were retrospectively reviewed. The background of the patients was similar. Operative time, intra- and postoperative blood loss were not significantly different. With HS conization all specimens were removed in one piece, but with LEEP the median number of specimens obtained per patient was 3.3 (p < 0.0001) with a maximum of 5. The depth of thermal artifacts at the endocervical margin was significantly less with HS conization (0.20 mm) than with LEEP (0.30 mm; p = 0.0006). This new method produced an ideal-shaped specimen without increasing complications and thermal artifacts compared with LEEP. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)264-268
Number of pages5
JournalGynecologic and Obstetric Investigation
Issue number4
Publication statusPublished - 2000 Jan 1


  • Cervical intraepithelial neoplasia
  • Conization
  • Harmonic Scalpel

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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