Stereomutation of a BIPHEP/RuCl2/diamine complex (shown schematically) is possible because of the conformational flexibilty of BIPHEP ligands. The result is an asymmetric activation in the Ru-catalyzed hydrogenation of carbonyl compounds to optically active alcohols. Whereas a racemic BINAP/RuCl2 complex with a chiral diamine activator gives a 1:1 mixture of two diastereomers, unequal amounts of the diastereomers can be produced from a BIPHEP/RuCl2 complex and a chiral diamine. Ar = 3,5-dimethylphenyl, BINAP = 2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl, BIPHEP = 2,2'- bis(diarylphosphanyl)biphenyl.
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 1999 Feb 15|
- Asymmetric catalysis
- P ligands
ASJC Scopus subject areas