Conformational features of the four successive non-Watson-Crick base pairs in RNA duplex.

S. Fujii, Y. Tanaka, S. Uesugi, T. Tanaka, T. Sakata, H. Hiroaki

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A tridecaribonucleotide, r(UGAGCUUCGGCUC) doesn't form hairpin or interior loop and forms a double helix of 12 base pairs including the four successive nonstandard base pairs, U.G-U.C-C.U-G.U, in the crystal. Non-Watson-Crick base pairs, G.U and U.C are nicely incorporated in RNA duplex maintaining the regular A-form backbone. There exist the good overlapping between base pairings, U.G and U.C, so as to stabilize the nonstandard base pair track. Hydrogen bond networks involving water molecules in the major and minor grooves to stabilize this mismatch base pairing array, are observed and its conformational features are described.

Original languageEnglish
Pages (from-to)63-64
Number of pages2
JournalNucleic acids symposium series
Issue number27
Publication statusPublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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