Confirmation of the absence of tetrodotoxin and its analogues in the juveniles of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs in the laboratory using HILIC-LC-MS

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Abstract

The tetrodotoxin (TTX) contents of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs to metamorphosed juveniles with a non-toxic diet for 70 weeks, as well as wild-caught juvenile newts, were investigated using a high-resolution hydrophilic interaction chromatography-LC-MS. TTX was detected in 0- to 22-week-old captive-reared juvenile newts but was not detected (<15 ng/g) in the 36- to 70-week-old newts, while significant levels of TTX (1.3-14 μg/g) were detected in the wild-caught juveniles.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalToxicon
Volume101
DOIs
Publication statusPublished - 2015 May 22

Keywords

  • Cynops pyrrhogaster
  • LC-MS
  • Newt
  • Tetrodotoxin
  • Toxicity analysis

ASJC Scopus subject areas

  • Toxicology

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