Condensed heteroaromatic ring systems. XXIV. Palladium-catalyzed cyclization of 2-substituted phenylacetylenes in the presence of carbon monoxide

Yoshinori Kondo, Futoshi Shiga, Naoko Murata, Takao Sakamoto, Hiroshi Yamanaka

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

The palladium-catalyzed reaction of 2-alkynylanilines and 2-alkynylphenols in the presence of carbon monoxide and methanol under basic conditions gave the sequential cyclization / carbonylation products, methyl 2-substituted indole and benzo[b]-furan-3-carboxylates. Similar reaction of 2-alkynylbenzamides gave 3-alkylidenisoindole derivatives.

Original languageEnglish
Pages (from-to)11803-11812
Number of pages10
JournalTetrahedron
Volume50
Issue number41
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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