Condensed Heteroaromatic Ring Systems. XXI. Synthesis of Pyrrolo [2,3-d] pyrimidines and Pyrrolo [3,2-d] pyrimidines

Takao Sakamoto, Chisato Satoh, Yoshinori Kondo, Hiroshi Yamanaka

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Pyrrolo[2,3-d]pyrimidines and pyrrolo [3,2-d] pyrimidines were synthesized in high yields by the palladium-catalyzed reaction of 4-acetylamino-5-bromopyrimidines and 5-acetylamino-4-iodopyrimidines with (Z)-1-ethoxy-2-(tributylstannyl)ethene followed by cyclization under acidic conditions.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume41
Issue number1
DOIs
Publication statusPublished - 1993

Keywords

  • palladium-catalyzed reaction
  • pyrrolo[2,3-d]pyrimidine
  • pyrrolo[3,2-d]pyrimidine

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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