Condensed Heteroaromatic Ring Systems. XV.1) Synthesis of Pyranopyridinones from Halopyridinecarbonitriles

Takao Sakamotc; Masayuki An-naka; Yoshinori Kondo; Tomio Araki; Hiroshi Yamanaka

doi:10.1248/cpb.36.1890

Condensed Heteroaromatic Ring Systems. XV.¹⁾ Synthesis of Pyranopyridinones from Halopyridinecarbonitriles

Takao Sakamotc, Masayuki An-naka, Yoshinori Kondo, Tomio Araki, Hiroshi Yamanaka

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Four kinds of pyranopyridinones were synthesized from pyridinecarbonitriles containing a chlorine or bromine substituent at the adjacent position to the cyano group by the palladium-catalyzed cross-coupling reaction with terminal acetylenes followed by intramolecular cyclization with polyphosphoric acid.

Original language	English
Pages (from-to)	1890-1894
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	36
Issue number	5
DOIs	https://doi.org/10.1248/cpb.36.1890
Publication status	Published - 1988 Jan 1

Keywords

ethynylpyridinecarbonitrile
halopyridinecarbonitrile
palladium-catalyzed reaction
polyphosphoric acid
pyranopyridinone
terminal acetylene

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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abstract = "Four kinds of pyranopyridinones were synthesized from pyridinecarbonitriles containing a chlorine or bromine substituent at the adjacent position to the cyano group by the palladium-catalyzed cross-coupling reaction with terminal acetylenes followed by intramolecular cyclization with polyphosphoric acid.",

keywords = "ethynylpyridinecarbonitrile, halopyridinecarbonitrile, palladium-catalyzed reaction, polyphosphoric acid, pyranopyridinone, terminal acetylene",

author = "Takao Sakamotc and Masayuki An-naka and Yoshinori Kondo and Tomio Araki and Hiroshi Yamanaka",

year = "1988",

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T1 - Condensed Heteroaromatic Ring Systems. XV.1) Synthesis of Pyranopyridinones from Halopyridinecarbonitriles

AU - Sakamotc, Takao

AU - An-naka, Masayuki

AU - Kondo, Yoshinori

AU - Araki, Tomio

AU - Yamanaka, Hiroshi

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Four kinds of pyranopyridinones were synthesized from pyridinecarbonitriles containing a chlorine or bromine substituent at the adjacent position to the cyano group by the palladium-catalyzed cross-coupling reaction with terminal acetylenes followed by intramolecular cyclization with polyphosphoric acid.

AB - Four kinds of pyranopyridinones were synthesized from pyridinecarbonitriles containing a chlorine or bromine substituent at the adjacent position to the cyano group by the palladium-catalyzed cross-coupling reaction with terminal acetylenes followed by intramolecular cyclization with polyphosphoric acid.

KW - ethynylpyridinecarbonitrile

KW - halopyridinecarbonitrile

KW - palladium-catalyzed reaction

KW - polyphosphoric acid

KW - pyranopyridinone

KW - terminal acetylene

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JO - Chemical and Pharmaceutical Bulletin

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