Condensed Heteroaromatic Ring Systems. XV.1) Synthesis of Pyranopyridinones from Halopyridinecarbonitriles

Takao Sakamotc, Masayuki An-naka, Yoshinori Kondo, Tomio Araki, Hiroshi Yamanaka

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Four kinds of pyranopyridinones were synthesized from pyridinecarbonitriles containing a chlorine or bromine substituent at the adjacent position to the cyano group by the palladium-catalyzed cross-coupling reaction with terminal acetylenes followed by intramolecular cyclization with polyphosphoric acid.

Original languageEnglish
Pages (from-to)1890-1894
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Issue number5
Publication statusPublished - 1988 Jan 1


  • ethynylpyridinecarbonitrile
  • halopyridinecarbonitrile
  • palladium-catalyzed reaction
  • polyphosphoric acid
  • pyranopyridinone
  • terminal acetylene

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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