The synthesis of pyrrolo[2,3-→]pynniidine derivatives was accomplished by the following two methods. One is the palladium-catalyzed reaction of terminal acetylenes with N-(5-halo-4-pyrimidinyl)methanesulfonamides prepared by the nucleophilic substitution of 4-chloro-5-halopyrimidines with methanesulfonamide. The other is the photocyclization of 4-azidopyrimidines containing an olefinic function at the 5-position. The synthesis of 4-azidopyrimidine derivatives is also described.
- 3-d]pyrimidine palladium-catalyzed reaction N-(5-halo-4-pyrimidinyl)methanesulfonamide acetylene
- photochemical cyclization 4-azidopyrimidine nucleophilic substitution 4-chloropyrimidine methanesulfonamide pyrrolo[2
ASJC Scopus subject areas
- Drug Discovery