Condensed Heteroaromatic Ring Systems: XVI: Synthesis of Pyrrolo[2,3-d]pyrimidine Derivatives

Yoshinori Kondo, Ryo Watanabe, Takao Sakamoto, Hiroshi Yamanaka

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


The synthesis of pyrrolo[2,3-→]pynniidine derivatives was accomplished by the following two methods. One is the palladium-catalyzed reaction of terminal acetylenes with N-(5-halo-4-pyrimidinyl)methanesulfonamides prepared by the nucleophilic substitution of 4-chloro-5-halopyrimidines with methanesulfonamide. The other is the photocyclization of 4-azidopyrimidines containing an olefinic function at the 5-position. The synthesis of 4-azidopyrimidine derivatives is also described.

Original languageEnglish
Pages (from-to)2933-2936
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Issue number11
Publication statusPublished - 1989


  • 3-d]pyrimidine palladium-catalyzed reaction N-(5-halo-4-pyrimidinyl)methanesulfonamide acetylene
  • photochemical cyclization 4-azidopyrimidine nucleophilic substitution 4-chloropyrimidine methanesulfonamide pyrrolo[2

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery


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