Condensed Heteroaromatic Ring Systems. XIII.1) One-Step Synthesis of 2-Substituted 1-Methylsulfonylindoles from N-(2-Halophenyl)methanesulfonamides

Takao Sakamoto, Yoshinori Kondo, Shigeki Iwashita, Hiroshi Yamanaka, Tatsuo Nagano

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)

Abstract

The reaction of N-(2-bromopheny- and N-(2-iodophenyl)methanesulfonamide with terminal acetylenes in the presence of dichlorobis(triphenylphosphine)palladium yielded 1-methylsulfonyl-indoles having carbon-functional groups at the 2-position, such as hydroxymethyl, 2-hydroxyethyl, diethoxymethyl, 2-ethoxycarbonylethyl, etc., in one step.

Original languageEnglish
Pages (from-to)1305-1308
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume36
Issue number4
DOIs
Publication statusPublished - 1988 Jan 1

Keywords

  • 2-substituted 1-methylsulfonylindole
  • N-(2-halophenyl)methanesulfonamide
  • acetylene
  • dichlorobis(triphenylphosphine)palladium
  • palladium-catalyzed reaction

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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