The reaction of N-(2-bromopheny- and N-(2-iodophenyl)methanesulfonamide with terminal acetylenes in the presence of dichlorobis(triphenylphosphine)palladium yielded 1-methylsulfonyl-indoles having carbon-functional groups at the 2-position, such as hydroxymethyl, 2-hydroxyethyl, diethoxymethyl, 2-ethoxycarbonylethyl, etc., in one step.
- 2-substituted 1-methylsulfonylindole
- palladium-catalyzed reaction
ASJC Scopus subject areas
- Drug Discovery