Abstract
The hydration of o-ethynylbenzoic acid derivatives, such as ethyl o-ethynylbenzoate, o-ethynylbenzonitrile, and o-ethynylbenzamide, in sulfuric acid in the presence of mercuric sulfate, afforded 3-substituted isocoumarins. The palladium-catalyzed reaction of o-halobenzoic acid derivatives with terminal acetylenes to obtain the starting materials for the cyclization is also described.
| Original language | English |
|---|---|
| Pages (from-to) | 2754-2759 |
| Number of pages | 6 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 34 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1986 Jan 1 |
Keywords
- acetylene
- ethyl o-ethynylbenzoate
- isocoumarin
- mercuric sulfate
- o-ethynylbenzamide
- o-ethynylbenzonitrile
- palladium-catalyzed reaction
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
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Cite this
Sakamoto, T., An-Naka, M., Kondo, Y., & Yamanaka, H. (1986). Condensed Heteroaromatic Ring Systems. VIII.1) Synthesis of 3-Substituted Isocoumarins from o-Halobenzoic Acid Derivatives. Chemical and Pharmaceutical Bulletin, 34(7), 2754-2759. https://doi.org/10.1248/cpb.34.2754