Abstract
The hydration of o-ethynylbenzoic acid derivatives, such as ethyl o-ethynylbenzoate, o-ethynylbenzonitrile, and o-ethynylbenzamide, in sulfuric acid in the presence of mercuric sulfate, afforded 3-substituted isocoumarins. The palladium-catalyzed reaction of o-halobenzoic acid derivatives with terminal acetylenes to obtain the starting materials for the cyclization is also described.
Original language | English |
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Pages (from-to) | 2754-2759 |
Number of pages | 6 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 34 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1986 Jan 1 |
Keywords
- acetylene
- ethyl o-ethynylbenzoate
- isocoumarin
- mercuric sulfate
- o-ethynylbenzamide
- o-ethynylbenzonitrile
- palladium-catalyzed reaction
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery