Condensed Heteroaromatic Ring Systems. IV.1) Synthesis of Naphthyridine Derivatives by Cyclization of Aminopyridineacrylic Esters

Takao Sakamoto; Yoshinori Kondo; Hiroshi Yamanaka

doi:10.1248/cpb.33.4764

Condensed Heteroaromatic Ring Systems. IV.¹⁾ Synthesis of Naphthyridine Derivatives by Cyclization of Aminopyridineacrylic Esters

Takao Sakamoto, Yoshinori Kondo, Hiroshi Yamanaka

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The reaction of aminohalopyridines with ethyl acrylate in the presence of palladium(II) acetate and triarylphosphine gave ethyl aminopyridineacrylates. The cyclization of the resulting acrylates under basic conditions gave naphthyridinones having a carbostyril-type moiety.

Original language	English
Pages (from-to)	4764-4768
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	33
Issue number	11
DOIs	https://doi.org/10.1248/cpb.33.4764
Publication status	Published - 1985 Jan 1

Keywords

ethyl acrylate
intramolecular cyclization
naphthyridinone
palladium catalyst
pyridineacrylic ester

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.33.4764

Cite this

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abstract = "The reaction of aminohalopyridines with ethyl acrylate in the presence of palladium(II) acetate and triarylphosphine gave ethyl aminopyridineacrylates. The cyclization of the resulting acrylates under basic conditions gave naphthyridinones having a carbostyril-type moiety.",

keywords = "ethyl acrylate, intramolecular cyclization, naphthyridinone, palladium catalyst, pyridineacrylic ester",

author = "Takao Sakamoto and Yoshinori Kondo and Hiroshi Yamanaka",

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AU - Kondo, Yoshinori

AU - Yamanaka, Hiroshi

PY - 1985/1/1

Y1 - 1985/1/1

N2 - The reaction of aminohalopyridines with ethyl acrylate in the presence of palladium(II) acetate and triarylphosphine gave ethyl aminopyridineacrylates. The cyclization of the resulting acrylates under basic conditions gave naphthyridinones having a carbostyril-type moiety.

AB - The reaction of aminohalopyridines with ethyl acrylate in the presence of palladium(II) acetate and triarylphosphine gave ethyl aminopyridineacrylates. The cyclization of the resulting acrylates under basic conditions gave naphthyridinones having a carbostyril-type moiety.

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KW - intramolecular cyclization

KW - naphthyridinone

KW - palladium catalyst

KW - pyridineacrylic ester

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