Condensed Heteroaromatic Ring Systems. IV.1) Synthesis of Naphthyridine Derivatives by Cyclization of Aminopyridineacrylic Esters

Takao Sakamoto, Yoshinori Kondo, Hiroshi Yamanaka

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The reaction of aminohalopyridines with ethyl acrylate in the presence of palladium(II) acetate and triarylphosphine gave ethyl aminopyridineacrylates. The cyclization of the resulting acrylates under basic conditions gave naphthyridinones having a carbostyril-type moiety.

Original languageEnglish
Pages (from-to)4764-4768
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume33
Issue number11
DOIs
Publication statusPublished - 1985 Jan 1

Keywords

  • ethyl acrylate
  • intramolecular cyclization
  • naphthyridinone
  • palladium catalyst
  • pyridineacrylic ester

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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