Abstract
Four kinds of naphthyridinones, i.e. l,6-naphthyridin-5-one, l,7-naphthyridin-8-one, 2,6-naphthyridin-2-one, and 2,7-naphthyridin-l-one derivatives, were commonly synthesized by the intramolecular cyclization of pyridinecarboxamides having an ethynyl group or β,β-dimethoxyethyl group adjacent to the carbamoyl group. The syntheses of the starting pyridine derivatives were easily accomplished by cross-coupling of the corresponding halopyridines with acetylenes.
Original language | English |
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Pages (from-to) | 626-633 |
Number of pages | 8 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 33 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1985 |
Keywords
- L(2H)-isoquinolone
- intramolecular cyclization
- naphthyridinone
- palladium catalyst
- pyridineacetaldehyde
- trimethylsilylacetylene
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery