Condensed Heteroaromatic Ring Systems. III.1,2) Synthesis of Naphthyridine Derivatives by Cyclization of Ethynylpyridinecarboxamides

Takao Sakamoto, Yoshinori Kondo, Hiroshi Yamanaka

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Four kinds of naphthyridinones, i.e. l,6-naphthyridin-5-one, l,7-naphthyridin-8-one, 2,6-naphthyridin-2-one, and 2,7-naphthyridin-l-one derivatives, were commonly synthesized by the intramolecular cyclization of pyridinecarboxamides having an ethynyl group or β,β-dimethoxyethyl group adjacent to the carbamoyl group. The syntheses of the starting pyridine derivatives were easily accomplished by cross-coupling of the corresponding halopyridines with acetylenes.

Original languageEnglish
Pages (from-to)626-633
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Volume33
Issue number2
DOIs
Publication statusPublished - 1985 Jan 1

Keywords

  • L(2H)-isoquinolone
  • intramolecular cyclization
  • naphthyridinone
  • palladium catalyst
  • pyridineacetaldehyde
  • trimethylsilylacetylene

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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