Condensed heteroaromat1c ring systems. XI.1 A facile synthesis of isoquinoline N-oxides

Takao Sakamoto, Yoshinori Kondo, Norio Miura, Kazuhiko Hayashi, Hiroshi Yamanaka

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Isoquinoline 2-oxides (5a-f) were obtained by the cyclization of 2-ethynylbenzaldehyde oxime (4a-f) under basic conditions. The starting compounds (4a-f) were easily synthesized by the palladium-catalyzed reaction of 2-bromobenzaldehydes (1 and 2) with terminal acetylenes, and subsequent oximation of the resulting 2-ethynylbenzaldehydes (3a-f).

Original languageEnglish
Pages (from-to)2311-2314
Number of pages4
Issue number8
Publication statusPublished - 1986 Aug 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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