Concurrent connection of embryonic chick heart using a microfluidic device for Organ-Explant-Chip

Hirofumi Owaki, Taisuke Masuda, Tomohiro Kawahara, Kota Miyasaka, Toshihiko Ogura, Fumihito Arai

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)

Abstract

We propose a concurrent microvascular connection method called suction-induced vascular fixation (SVF) method for the achievement of Organ-Explant-Chip which is a biologically-designed simulator having biological materials such as cells, tissues, and organs. The advantages of proposed method with using a microfluidic device are as follows: (1) operation of flexible objects (blood vessels), (2) alignment the blood vessels concurrently, and (3) reduction of the DOFs of the blood vessels. From the experimental results, we confirmed that four cardiovascular of the explanted embryonic chick heart can be induced into the fabricated microfluidic device concurrently. We have also succeeded in construction of hybrid circulatory system between artifacts and embryonic chick heart, and monitoring the response of the heart of chick embryo by supplying the culture medium.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalProcedia CIRP
Volume5
DOIs
Publication statusPublished - 2013 Jan 1
Event1st CIRP Conference on BioManufacturing, BioM 2013 - Tokyo, Japan
Duration: 2013 Mar 32013 Mar 5

Keywords

  • Bionic simulator
  • Chick embryo
  • Microfluidic device
  • Microvascular connection

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Industrial and Manufacturing Engineering

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