TY - JOUR
T1 - Concurrent Community Transmission of Enterovirus D68 with Human Rhinoviruses and Respiratory Syncytial Virus among Children in Sendai, Japan
AU - Metoki, Takaya
AU - Okamoto, Michiko
AU - Suzuki, Akira
AU - Kitaoka, Setsuko
AU - Miyabayashi, Hiroki
AU - Rokugo, Yuka
AU - Onuma, Ryoichi
AU - Noguchi, Rie
AU - Sato, Taiki
AU - Watanabe, Yohei
AU - Ohmiya, Suguru
AU - Sato, Ko
AU - Nishimura, Hidekazu
AU - Oshitani, Hitoshi
AU - Kumaki, Satoru
N1 - Funding Information:
Accepted for publication June 12, 2017. From the *Department of Pediatrics, Sendai Medical Center, Sendai, Japan; †Department of Virology, Tohoku University Graduate School of Medi-cine, Sendai, Japan; ‡Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan; and §Virus Research Center, Clinical Research Division, Sendai Medical Center, Sendai, Japan. Supported by Grant-in-Aid for Scientific Research (C; 16K10012) of Japan Soci-ety for the Promotion of Science (JSPS); and Research Program on Emerg-ing and Re-emerging Infectious Diseases (16fk0108104h1001) from Japan Agency for Medical Research and Development (AMED). The authors have no conflicts of interest to disclose. Address for correspondence: Satoru Kumaki, MD, PhD, Department of Pediat-rics, Sendai Medical Center, 2-8-8 Miyagino, Miyagino-ku, Sendai, Miyagi 983–8520, Japan. Email address: kumaki@med.tohoku.ac.jp Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved. ISSN: 0891-3668/18/3705-0394 DOI: 10.1097/INF.0000000000001768
Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Background: In the autumn of 2015, we experienced a surge in the number of pediatric cases of wheeze in our hospital, which was suspected to be caused by enterovirus (EV)-D68 transmission in the community. Thus, we implemented an ad hoc retrospective surveillance for EV-D68. Methods: Patients <15 years of age with acute respiratory infection were eligible for inclusion in this study. All enrolled patients underwent virus detection test. Additionally, neutralization tests (NTs) were performed using the stored serum samples of the enrolled patients to compare the antigenicity of the virus isolated in this study with that isolated in 2010 and evaluate the anti-EV-D68 antibody prevalence. Results: Respiratory syncytial virus (RSV) was the most commonly detected virus (35%), followed by EV-D68 (19%) and non-EV-D68 enteroviruses/human rhinoviruses (14%). Patients with EV-D68 infection had higher median age than those with RSV infection (P < 0.05). Moreover, patients with EV-D68 infection showed a higher expiratory wheeze prevalence than those with non-EV-D68 enterovirus/rhinovirus and RSV infections. The antigenicity of the isolate from the current study was similar to the virus that circulated in 2010. At the early study phase, children in our community did not have high NT titers, but the median log NT titer increased from 1.5 to 5 over time (P < 0.05). Conclusion: This study showed the concurrent circulation of EV-D68 with non-EV-D68 enteroviruses/rhinoviruses and RSV in infants and children in our community and captured the early stage of EV-D68 transmission.
AB - Background: In the autumn of 2015, we experienced a surge in the number of pediatric cases of wheeze in our hospital, which was suspected to be caused by enterovirus (EV)-D68 transmission in the community. Thus, we implemented an ad hoc retrospective surveillance for EV-D68. Methods: Patients <15 years of age with acute respiratory infection were eligible for inclusion in this study. All enrolled patients underwent virus detection test. Additionally, neutralization tests (NTs) were performed using the stored serum samples of the enrolled patients to compare the antigenicity of the virus isolated in this study with that isolated in 2010 and evaluate the anti-EV-D68 antibody prevalence. Results: Respiratory syncytial virus (RSV) was the most commonly detected virus (35%), followed by EV-D68 (19%) and non-EV-D68 enteroviruses/human rhinoviruses (14%). Patients with EV-D68 infection had higher median age than those with RSV infection (P < 0.05). Moreover, patients with EV-D68 infection showed a higher expiratory wheeze prevalence than those with non-EV-D68 enterovirus/rhinovirus and RSV infections. The antigenicity of the isolate from the current study was similar to the virus that circulated in 2010. At the early study phase, children in our community did not have high NT titers, but the median log NT titer increased from 1.5 to 5 over time (P < 0.05). Conclusion: This study showed the concurrent circulation of EV-D68 with non-EV-D68 enteroviruses/rhinoviruses and RSV in infants and children in our community and captured the early stage of EV-D68 transmission.
KW - IgE
KW - enterovirus D68
KW - human respiratory syncytial virus
KW - human rhinovirus
KW - neutralization antibody
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U2 - 10.1097/INF.0000000000001768
DO - 10.1097/INF.0000000000001768
M3 - Article
C2 - 29189674
AN - SCOPUS:85061134530
VL - 37
SP - 394
EP - 400
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
SN - 0891-3668
IS - 5
ER -
