TY - JOUR
T1 - Concordant pattern of the HPA axis response to visceral stimulation and CRH administration
AU - Yagihashi, Mao
AU - Kano, Michiko
AU - Muratsubaki, Tomohiko
AU - Morishita, Joe
AU - Kono, Keishi
AU - Tanaka, Yukari
AU - Kanazawa, Motoyori
AU - Fukudo, Shin
N1 - Funding Information:
This research was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science ( 26460898 for MK, 15H04799 and 19K22589 for SF) and NCNP 2-2 for SF. The funding source played no role in study design, in the collection, analysis, or interpretation of data, in the writing of the report, or in the decision to publish.
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/7
Y1 - 2021/7
N2 - The physiological and psychological mechanisms explaining the individual variability in the stress response are poorly understood. We tested the hypothesis that hypothalamic-pituitary- adrenal (HPA) axis responses to colorectal stimulation affect HPA axis reactivity to corticotropin-releasing hormone (CRH), the visceral pain threshold, and perceived stress. We examined 31 healthy volunteers and 27 individuals with irritable bowel syndrome. According to the ACTH response to colorectal stimulation, the participants were classified into three groups: flattened, decreased, and increased. We found significant differences in the abdominal pain threshold, discomfort threshold, and sensitivity to anxiety among the groups. There were significant differences in the ACTH change and peak level after CRH administration among the groups. The area under the curve of the cortisol response to CRH was significantly different among the groups. The increased group showed a higher basal ACTH level, earlier peak level in the CRH administration test, and higher stress rating during the experiment. The increased group had an exaggerated psychological and physiological stress response, whereas the decreased group had a higher anticipatory endocrine response, stress, and sensitivity to anxiety. Further studies are needed to determine factors including gut microbiota on the individual difference in HPA response.
AB - The physiological and psychological mechanisms explaining the individual variability in the stress response are poorly understood. We tested the hypothesis that hypothalamic-pituitary- adrenal (HPA) axis responses to colorectal stimulation affect HPA axis reactivity to corticotropin-releasing hormone (CRH), the visceral pain threshold, and perceived stress. We examined 31 healthy volunteers and 27 individuals with irritable bowel syndrome. According to the ACTH response to colorectal stimulation, the participants were classified into three groups: flattened, decreased, and increased. We found significant differences in the abdominal pain threshold, discomfort threshold, and sensitivity to anxiety among the groups. There were significant differences in the ACTH change and peak level after CRH administration among the groups. The area under the curve of the cortisol response to CRH was significantly different among the groups. The increased group showed a higher basal ACTH level, earlier peak level in the CRH administration test, and higher stress rating during the experiment. The increased group had an exaggerated psychological and physiological stress response, whereas the decreased group had a higher anticipatory endocrine response, stress, and sensitivity to anxiety. Further studies are needed to determine factors including gut microbiota on the individual difference in HPA response.
KW - Allostatic load
KW - Anxiety sensitivity
KW - Corticotropin-releasing hormone
KW - Hypothalamic-pituitary-adrenal axis
KW - Individual variability
KW - Perceived stress
KW - Rectal distention
KW - Visceral perception
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U2 - 10.1016/j.neures.2021.03.004
DO - 10.1016/j.neures.2021.03.004
M3 - Article
C2 - 33785411
AN - SCOPUS:85103714593
VL - 168
SP - 32
EP - 40
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
ER -