Concise total synthesis of acortatarin A

Takaaki Teranishi; Masayuki Kageyama; Shigefumi Kuwahara

doi:10.1271/bbb.120862

Concise total synthesis of acortatarin A

Takaaki Teranishi, Masayuki Kageyama, Shigefumi Kuwahara

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The spirocyclic pyrrole alkaloid, acortatarin A, which had been isolated from a Chinese medicinal plant, was synthesized from a known olefinic compound by a concise six-step sequence involving N-alkylation of a pyrrole derivative with an α-bromo ketone intermediate as the key step.

Original language	English
Pages (from-to)	676-678
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	77
Issue number	3
DOIs	https://doi.org/10.1271/bbb.120862
Publication status	Published - 2013

Keywords

Acortatarin
N-alkylation
Reactive oxygen species
Spiro acetal

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.120862

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title = "Concise total synthesis of acortatarin A",

abstract = "The spirocyclic pyrrole alkaloid, acortatarin A, which had been isolated from a Chinese medicinal plant, was synthesized from a known olefinic compound by a concise six-step sequence involving N-alkylation of a pyrrole derivative with an α-bromo ketone intermediate as the key step.",

keywords = "Acortatarin, N-alkylation, Reactive oxygen species, Spiro acetal",

author = "Takaaki Teranishi and Masayuki Kageyama and Shigefumi Kuwahara",

note = "Funding Information: This work was supported, in part, by grant-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (no. 22380064).",

year = "2013",

doi = "10.1271/bbb.120862",

language = "English",

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pages = "676--678",

journal = "Bioscience, Biotechnology and Biochemistry",

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T1 - Concise total synthesis of acortatarin A

AU - Teranishi, Takaaki

AU - Kageyama, Masayuki

AU - Kuwahara, Shigefumi

N1 - Funding Information: This work was supported, in part, by grant-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (no. 22380064).

PY - 2013

Y1 - 2013

N2 - The spirocyclic pyrrole alkaloid, acortatarin A, which had been isolated from a Chinese medicinal plant, was synthesized from a known olefinic compound by a concise six-step sequence involving N-alkylation of a pyrrole derivative with an α-bromo ketone intermediate as the key step.

AB - The spirocyclic pyrrole alkaloid, acortatarin A, which had been isolated from a Chinese medicinal plant, was synthesized from a known olefinic compound by a concise six-step sequence involving N-alkylation of a pyrrole derivative with an α-bromo ketone intermediate as the key step.

KW - Acortatarin

KW - N-alkylation

KW - Reactive oxygen species

KW - Spiro acetal

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 3

ER -

Concise total synthesis of acortatarin A

Abstract

Keywords

ASJC Scopus subject areas

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