Concise synthesis of the C15-C38 fragment of okadaic acid: Application of the Suzuki-Miyaura reaction to spiroacetal synthesis

Haruhiko Fuwa, Keita Sakamoto, Takashi Muto, Makoto Sasaki

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    A concise synthetic entry to the C15-C38 fragment of okadaic acid by exploiting a Suzuki-Miyaura reaction for the rapid assembly of the spiroacetal substructures has been developed. The present synthesis was completed in 19 linear steps from a commercially available material, showcasing the efficiency of our synthetic strategy.

    Original languageEnglish
    Pages (from-to)366-369
    Number of pages4
    JournalOrganic letters
    Volume17
    Issue number2
    DOIs
    Publication statusPublished - 2015 Jan 16

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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