(Chemical Equation Presented) The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-L-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved from N-Boc-L-valine by the same approach, which enabled its stereochemical determination.
|Number of pages||4|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 2009 Oct 2|
ASJC Scopus subject areas
- Organic Chemistry