Concise synthesis of PM-94128 and Y-05460M-A

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

(Chemical Equation Presented) The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-L-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved from N-Boc-L-valine by the same approach, which enabled its stereochemical determination.

Original languageEnglish
Pages (from-to)7566-7569
Number of pages4
JournalJournal of Organic Chemistry
Volume74
Issue number19
DOIs
Publication statusPublished - 2009 Oct 2

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Concise synthesis of PM-94128 and Y-05460M-A'. Together they form a unique fingerprint.

Cite this