Concise synthesis of PM-94128 and Y-05460M-A

Masaru Enomoto; Shigefumi Kuwahara

doi:10.1021/jo9014968

Concise synthesis of PM-94128 and Y-05460M-A

Masaru Enomoto, Shigefumi Kuwahara

AGR - Agricultural Chemistry

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

(Chemical Equation Presented) The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-L-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved from N-Boc-L-valine by the same approach, which enabled its stereochemical determination.

Original language	English
Pages (from-to)	7566-7569
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	74
Issue number	19
DOIs	https://doi.org/10.1021/jo9014968
Publication status	Published - 2009 Oct 2

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo9014968

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abstract = "(Chemical Equation Presented) The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-L-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved from N-Boc-L-valine by the same approach, which enabled its stereochemical determination.",

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Concise synthesis of PM-94128 and Y-05460M-A

Abstract

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