Concise synthesis of CC-1065/duocarmycin pharmacophore using the intramolecular heck reaction

Takao Sakamoto, Yoshinori Kondo, Masanobu Uchiyama, Hiroshi Yamanaka

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

3-Methyleneindoline derivatives were synthesized by intramolecular Heck reaction of N-allyl-2-iodoaniline derivatives in the presence of Ag 2CO3. This method was successfully applied to the synthesis of the CC-1065/duocarmycin pharmacophore.

Original languageEnglish
Pages (from-to)1941-1942
Number of pages2
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number17
DOIs
Publication statusPublished - 1993 Jan 1

ASJC Scopus subject areas

  • Chemistry(all)

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