Concise stereoselective synthesis of (2S,4R)-4-hydroxyproline from (S)-O-benzylglycidol a novel cyclization

Seiichi Takano, Yoshiharu Iwabuchi, Kunio Ogasawara

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

An efficient stereoselective route to (2S,4R)-4-hydroxyproline from (S)-O-benzylglycidol has been established via a novel iodine-mediated cyclization of the N-benzoyl- γ,δ-unsaturated amide.

Original languageEnglish
Pages (from-to)1527-1528
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number23
DOIs
Publication statusPublished - 1988 Dec 1

ASJC Scopus subject areas

  • Molecular Medicine

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