TY - JOUR
T1 - Concept of left atrial pressure estimation using its pulsatile amplitude in the helical flow total artificial heart
AU - Wu, Sheng Yuan
AU - Saito, Itsuro
AU - Isoyama, Takashi
AU - Inoue, Yusuke
AU - Sato, Masami
AU - Hara, Shintaro
AU - Li, Xin Yang
AU - Yurimoto, Terumi
AU - Murakami, Haruka
AU - Kawase, Yukino
AU - Ono, Toshiya
AU - Abe, Yusuke
PY - 2014/12/5
Y1 - 2014/12/5
N2 - The total artificial heart (TAH) requires physiological control to respond to the metabolic demand of the body. To date, 1/R control is a single physiological control method that can control venous pressure. To realize an implantable 1/R control system, we are developing a new pressure measuring method using absolute pressure sensor. To find a method for absolute pressure sensor, which went well without calibration, concept of left atrial pressure (LAP) estimation using its pulsatile amplitude was proposed. Its possibility was investigated with two long-term survived goats whose hearts were replaced with the helical flow TAHs. In manual control condition, there existed a positive relation between mean LAP (mLAP) and normalized pulsatile amplitude (NPA). Percent systole revealed not to affect the relationship between mLAP and NPA. Dispersion was observed between different pulse rates. As for cardiac output difference (QLD) that is the difference of flow rate between systolic and diastolic phases, similar results were obtained except in low QLDs. In the 1/R control condition, relatively high correlation between mLAP and NPA could be obtained. In estimation of mLAP using the correlating function of individual goat, fairly good correlation was obtained between measured mLAP and estimated mLAP. Despite that further studies are necessary, it was demonstrated that the concept of the LAP estimation could be possible.
AB - The total artificial heart (TAH) requires physiological control to respond to the metabolic demand of the body. To date, 1/R control is a single physiological control method that can control venous pressure. To realize an implantable 1/R control system, we are developing a new pressure measuring method using absolute pressure sensor. To find a method for absolute pressure sensor, which went well without calibration, concept of left atrial pressure (LAP) estimation using its pulsatile amplitude was proposed. Its possibility was investigated with two long-term survived goats whose hearts were replaced with the helical flow TAHs. In manual control condition, there existed a positive relation between mean LAP (mLAP) and normalized pulsatile amplitude (NPA). Percent systole revealed not to affect the relationship between mLAP and NPA. Dispersion was observed between different pulse rates. As for cardiac output difference (QLD) that is the difference of flow rate between systolic and diastolic phases, similar results were obtained except in low QLDs. In the 1/R control condition, relatively high correlation between mLAP and NPA could be obtained. In estimation of mLAP using the correlating function of individual goat, fairly good correlation was obtained between measured mLAP and estimated mLAP. Despite that further studies are necessary, it was demonstrated that the concept of the LAP estimation could be possible.
KW - Atrial pressure
KW - Compliance
KW - Estimation
KW - Sensor
KW - Total artificial heart
UR - http://www.scopus.com/inward/record.url?scp=84913595479&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84913595479&partnerID=8YFLogxK
U2 - 10.1007/s10047-014-0788-7
DO - 10.1007/s10047-014-0788-7
M3 - Article
C2 - 25182409
AN - SCOPUS:84913595479
VL - 17
SP - 301
EP - 307
JO - Journal of Artificial Organs
JF - Journal of Artificial Organs
SN - 1434-7229
IS - 4
ER -