Concentration Threshold and Amplification Exhibited by a Helicene Oligomer during Helix-Dimer Formation: A Proposal on How a Cell Senses Concentration Changes of a Chemical

Yo Kushida, Masanori Shigeno, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Sulfonamidohelicene tetramer (M)-1 exhibits a concentration threshold and amplification phenomena in solution during helix-dimer formation from a random-coil. The (M)-tetramer is a random-coil below a threshold concentration, and the concentration of the helix-dimer is irreversibly amplified once the threshold concentration is exceeded. For example, a 15 % increase in (M)-tetramer total concentration from 0.6 to 0.7mM induces an 8-foldAR increase in the concentration of the helix-dimer, being 8:0.15=53-fold amplification, under temperature oscillation conditions between 47 and 49°C. Experiments without oscillation also exhibit concentration amplification. The threshold and amplification phenomenon involves concentration hysteresis, being away from equilibrium, and self-catalysis. On the basis of this study, a proposal on how a biological cell senses concentration changes of a chemical substance is provided. Concentration change: Sulfonamidohelicene tetramer (M)-1 exhibits a concentration threshold and amplification phenomena in solution. A proposal on how a biological cell senses concentration changes of a chemical substance in cells is provided (see scheme; Boc=tert-butoxycarbonyl).

Original languageEnglish
Pages (from-to)13788-13792
Number of pages5
JournalChemistry - A European Journal
Volume21
Issue number39
DOIs
Publication statusPublished - 2015 Sep 1

Keywords

  • concentration amplification
  • concentration hysteresis
  • helical structures
  • self-catalysis
  • sulfonamides

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Concentration Threshold and Amplification Exhibited by a Helicene Oligomer during Helix-Dimer Formation: A Proposal on How a Cell Senses Concentration Changes of a Chemical'. Together they form a unique fingerprint.

Cite this