Concentration of serum lipids and aortic lesion size in female and male apo e-deficient mice fed docosahexaenoic acid

Yosef Adan, Kenichi Shibata, Weihua Ni, Yasuyuki Tsuda, Masao Sato, Ikuo Ikeda, Katsumi Imaizumi

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Apolipoprotein (apo) E-deficient mice were fed an atherogenic diet with either 1% ethyl ester docosahexaenoic acid (DHA) or safflower oil (SO) as a source of linoleic acid for 8 week. Both genders fed DHA had higher proportions of eicosapentaenoic acid and DHA, and lower proportions of linoleic and arachidonic acids in the liver and serum phospholipids than those fed SO. Males fed DHA had greater liver weight and tended to have higher concentrations of serum lipids and liver cholesterol than those fed SO, and there were opposite trends in females. Dietary fats and gender led to no significant effect on lesion sizes in aortic arch and thoracic plus abdominal aorta. These results indicate that the interactive action of sex-related factor(s) with dietary polyunsaturated fatty acids is involved in metabolic changes of serum lipids in apoE-deficient mice, and addition of DHA, compared with addition of SO, is not effective to abolish the atherosclerosis in this animal model.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume63
Issue number2
DOIs
Publication statusPublished - 1999 Jan 1

Keywords

  • Apolipoprotein E-defficient mice
  • Atherosclerotic lesion
  • Docosahexaenoic acid
  • Gender
  • Lipids

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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