Concatenated mitochondrial DNA of the coccidian parasite Eimeria tenella

Kenji Hikosaka, Yutaka Nakai, Yoh ichi Watanabe, Shin Ichiro Tachibana, Nobuko Arisue, Nirianne Marie Q. Palacpac, Tomoko Toyama, Hajime Honma, Toshihiro Horii, Kiyoshi Kita, Kazuyuki Tanabe

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Apicomplexan parasites of the genus Plasmodium, pathogens causing malaria, and the genera Babesia and Theileria, aetiological agents of piroplasmosis, are closely related. However, their mitochondrial (mt) genome structures are highly divergent: Plasmodium has a concatemer of 6-kb unit and Babesia/. Theileria a monomer of 6.6- to 8.2-kb with terminal inverted repeats. Fragmentation of ribosomal RNA (rRNA) genes and gene arrangements are remarkably distinctive. To elucidate the evolutionary origin of this structural divergence, we determined the mt genome of Eimeria tenella, pathogens of coccidiosis in domestic fowls. Analysis revealed that E. tenella mt genome was concatemeric with similar protein-coding genes and rRNA gene fragments to Plasmodium. Copy number was 50-fold of the nuclear genome. Evolution of structural divergence in the apicomplexan mt genomes is discussed.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalMitochondrion
Volume11
Issue number2
DOIs
Publication statusPublished - 2011 Mar

Keywords

  • Apicomplexa
  • Eimeria
  • Mitochondrial genome
  • Mitochondrion
  • Nuclear mitochondrial DNA
  • Plasmodium

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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