TY - JOUR
T1 - Computed tomography findings of current nonspecific interstitial pneumonia based on the 2013 updated classification of idiopathic interstitial pneumonias
T2 - What is a characteristic of previously diagnosed nonspecific interstitial pneumonia excluded from the updated classification
AU - on behalf of the Study Group of Creation of Radiological Paper from Japan in Diffuse Lung Disease
AU - Tominaga, Junya
AU - Iwasawa, Tae
AU - Murota, Makiko
AU - Arakawa, Hiroaki
AU - Johkoh, Takeshi
AU - Yamano, Yasuhiko
AU - Zaizen, Yoshiaki
AU - Ichikado, Kazuya
AU - Hashisako, Mikiko
AU - Kondoh, Yasuhiro
AU - Kataoka, Kensuke
AU - Okamoto, Masaki
AU - Fujimoto, Kiminori
AU - Fukuoka, Junya
N1 - Publisher Copyright:
© 2020, Japan Radiological Society.
PY - 2021/1
Y1 - 2021/1
N2 - Purpose: To evaluate computed tomography (CT) findings of nonspecific interstitial pneumonia (NSIP) based on the current classification of idiopathic interstitial pneumonias (IIPs) and elucidate a characteristic of previously diagnosed NSIP excluded from the current classification. Materials and methods: The study included 74 patients with biopsy-proven NSIP (idiopathic NSIP [I-NSIP], 39 patients; NSIP associated with connective tissue disease [CTD-NSIP], 35 patients). Among patients who were compatible with the current classification of IIPs, 29 and 21 were categorized as having current I-NSIP and current CTD-NSIP, respectively. The remaining 24 patients were categorized as having previous I-NSIP or previous CTD-NSIP due to the primary pathologic diagnosis of cellular NSIP or associated findings of acute inflammatory changes. CT findings were evaluated and compared among the four groups. Results: Current I-NSIP was indicated by ground-glass attenuation and reticulation with traction bronchiectasis/bronchiolectasis in predominantly peribronchovascular areas of the lower lung zone. The previous I-NSIP group tended to show broader airspace consolidation than the current I-NSIP group (p = 0.068). The previous CTD-NSIP group showed significantly broader airspace consolidation than the current I-NSIP group (p = 0.035). Conclusion: Broad airspace consolidation is a characteristic of previously diagnosed CTD-NSIP excluded from the current classification of IIPs.
AB - Purpose: To evaluate computed tomography (CT) findings of nonspecific interstitial pneumonia (NSIP) based on the current classification of idiopathic interstitial pneumonias (IIPs) and elucidate a characteristic of previously diagnosed NSIP excluded from the current classification. Materials and methods: The study included 74 patients with biopsy-proven NSIP (idiopathic NSIP [I-NSIP], 39 patients; NSIP associated with connective tissue disease [CTD-NSIP], 35 patients). Among patients who were compatible with the current classification of IIPs, 29 and 21 were categorized as having current I-NSIP and current CTD-NSIP, respectively. The remaining 24 patients were categorized as having previous I-NSIP or previous CTD-NSIP due to the primary pathologic diagnosis of cellular NSIP or associated findings of acute inflammatory changes. CT findings were evaluated and compared among the four groups. Results: Current I-NSIP was indicated by ground-glass attenuation and reticulation with traction bronchiectasis/bronchiolectasis in predominantly peribronchovascular areas of the lower lung zone. The previous I-NSIP group tended to show broader airspace consolidation than the current I-NSIP group (p = 0.068). The previous CTD-NSIP group showed significantly broader airspace consolidation than the current I-NSIP group (p = 0.035). Conclusion: Broad airspace consolidation is a characteristic of previously diagnosed CTD-NSIP excluded from the current classification of IIPs.
KW - Chronic fibrosing interstitial pneumonia
KW - Computed tomography
KW - Nonspecific interstitial pneumonia
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U2 - 10.1007/s11604-020-01036-x
DO - 10.1007/s11604-020-01036-x
M3 - Article
C2 - 32875470
AN - SCOPUS:85090161492
VL - 39
SP - 47
EP - 55
JO - Japanese Journal of Radiology
JF - Japanese Journal of Radiology
SN - 1867-1071
IS - 1
ER -