Computational studies of effective asymmetric alkylation utilizing a chiral Schiff base derived from 2-hydroxy-3-pinanone - Part 1

Takatoshi Matsumoto, Takayuki Shioiri, Eiji Osawa

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The calculation by the semi-empirical molecular orbital method concerning the mechanism of the effective asymmetric alkylation utilizing a chiral Schiff base derived from 2-hydroxy-3-pinanone (2) has revealed that the factor which controls the stereoselectivity is mainly the influence of the lithium and THF ligands. The result has demonstrated the proposed hypothesis which is based on many experiments.

Original languageEnglish
Pages (from-to)5961-5970
Number of pages10
JournalTetrahedron
Volume52
Issue number16
DOIs
Publication statusPublished - 1996 Apr 15
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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