TY - GEN
T1 - Computational simulation of blood flow dynamics using an anatomically realistic artery model constructed from medical images
AU - Shimogonya, Yuji
AU - Itoh, Kazuhiro
AU - Kumamaru, Hiroshige
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Hemodynamics is believed to play a vital role in the initiation of cerebral aneurysms. In this study, we describe a newly defined hemodynamic quantity, the gradient oscillatory number (GON), as an index for the cerebral aneurysm initiation. It is defined by temporal variations of flow-induced tension/compression forces acting on endothelial cells. We calculated the index for the arterial geometry before aneurysm formation, which was constructed by artificially removing the aneurysm from a medical image-based arterial geometry. The result showed that the index had a strong correlation with the location of aneurysm formation. This suggests that the proposed index, GON, may be useful as a hemodynamic index for the initiation of cerebral aneurysms.
AB - Hemodynamics is believed to play a vital role in the initiation of cerebral aneurysms. In this study, we describe a newly defined hemodynamic quantity, the gradient oscillatory number (GON), as an index for the cerebral aneurysm initiation. It is defined by temporal variations of flow-induced tension/compression forces acting on endothelial cells. We calculated the index for the arterial geometry before aneurysm formation, which was constructed by artificially removing the aneurysm from a medical image-based arterial geometry. The result showed that the index had a strong correlation with the location of aneurysm formation. This suggests that the proposed index, GON, may be useful as a hemodynamic index for the initiation of cerebral aneurysms.
KW - Blood flow
KW - Cerebral aneurysm
KW - Computational fluid dynamics
KW - Medical image
UR - http://www.scopus.com/inward/record.url?scp=78651455022&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78651455022&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:78651455022
SN - 9781424496730
T3 - 2010 World Automation Congress, WAC 2010
BT - 2010 World Automation Congress, WAC 2010
T2 - 2010 World Automation Congress, WAC 2010
Y2 - 19 September 2010 through 23 September 2010
ER -