Computational mechanical model studies on the spontaneous emergent morphogenesis of the cultured endothelial cells

Takami Yamaguchi, Yasuhito Yamamoto, Hao Liu

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

To address questions concerning why and how the morphology of endothelial cells (ECs) forms under shear stress loading, a computational fluid dynamics (CFD) three-dimensional (3D) model of ECs simulating cell shape was designed. A full 3D non-linear CFD simulation was conducted to estimate the wall shear stress (WSS) distribution. The model cell was capable of random rotation, deformation, migration, and proliferation. Flow was computed after each update of the cell shape with infinitesimal configuration changes. After a finite interval of the flow computation, only the infinitesimal configuration changes that reduced the WSS were allowed to accumulate. As a result of the very long free-run computation experiment, starting with a sub-confluent pattern of cells, the model cells became confluent and were elongated and aligned, with a shape index (SI) very close to that reported for cells in vivo. The average WSS converged to the lowest value at the same time. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)115-126
Number of pages12
JournalJournal of Biomechanics
Volume33
Issue number1
DOIs
Publication statusPublished - 2000 Jan 1
Externally publishedYes

Keywords

  • Computational fluid dynamics
  • Emergent morphogenesis
  • Endothelial cell
  • Shape index
  • Wall shear stress

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Fingerprint Dive into the research topics of 'Computational mechanical model studies on the spontaneous emergent morphogenesis of the cultured endothelial cells'. Together they form a unique fingerprint.

  • Cite this