Compton-PET Imaging of 10C for Range Verification of Carbon Ion Therapy

Akram Mohammadi, Eiji Yoshida, Yusuke Okumura, Munetaka Nitta, Fumihiko Nishikido, Atsushi Kitagawa, Kei Kamada, Katia Parodi, Taiga Yamaya

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In carbon ion therapy, visualization of the range of incident particles in a patient body is important for treatment verification. In-beam positron emission tomography (PET) imaging in ion therapy is one of the method for verification of treatment due to the high quality of PET images. We have already shown the feasibility of radioactive beams of 15O and 11C using in-beam PET imaging using our OpenPET system. Recently, we have developed a whole gamma imaging (WGI) system which can work as PET, single gamma-ray and triple gamma-ray imaging simultaneously. The WGI system has high potential to detect location of 10C, which emits positron with a simultaneous gamma-ray of 718 keV, and activity of other produced positron emitting nuclei within patient body during ion therapy. In this work, we focus on investigation of performance of WGI system for 10C irradiation. First, the performance of scatterer detector of the WGI system regarding the radiation hardness was studied for 10C irradiation, then the performance of WGI was studied by simulation using the Geant4 code. The scatterer detector consisted of a segmented GAGG crystal and a multi-pixel photon counter (MPPC) and its performance was studied as a PMMA phantom was irradiated with 5 and 400 spills of 10C with energy of 350 MeV/u. No damage to the MPPC (scatterer detector) was observed even though after irradiation of 400 spills (∼1.9×105 particle per spill). Sensitivity values of WGI system by simulation of a 10C nuclide at the center of field of view (FOV) for PET mode imaging, single gamma-ray of 718 keV imaging and triple gamma-ray imaging were 7.85%, 0.28% and 0.012% respectively. The performance of WGI system is going to be evaluated for 10C irradiation in the near future.

Original languageEnglish
Title of host publication2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538684948
DOIs
Publication statusPublished - 2018 Nov
Externally publishedYes
Event2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Sydney, Australia
Duration: 2018 Nov 102018 Nov 17

Publication series

Name2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings

Conference

Conference2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018
CountryAustralia
CitySydney
Period18/11/1018/11/17

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Nuclear and High Energy Physics

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