Compliance effect on the flow condition in vascular in vitro experiments

Masami Matsuura, Simon Tupin, Makoto Ohta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Endovascular treatment has become the standard for intracranial aneurysm management. In vitro systems including an artery model are required for devices evaluation and clinician training. Although silicone is usually use for such model, its compliance is known to be lower than blood vessels. The purpose of this study was to analyze the influence of model material compliance on flow properties. Silicone and 12 [wt%] poly (vinyl alcohol) hydrogel (PVAH) were used to create two box-shaped models of significantly different compliance. The inner lumen geometry was a 4 [mm] diameter straight tube (parent vessel) and a 10 [mm] diameter sphere representing the aneurysm. A blood-mimicking fluid made of a mixture of glycerin, water and sodium iodide was used to reproduce the viscosity and density of blood and fit models refractive index. The circulation system consisted of a pulsatile blood pump and resistance valve. A flow rate of 250±50 [ml/min] and pressure from 75 to 115 [mmHg] were set inside the model. Pressure and flow rate sensors were used to monitor flow conditions before and after the model. Particle image velocimetry (PIV) was performed to record the difference of flow patterns inside the aneurysm of both model using a Nd:YAG solid laser system and fluorescent particles. Results revealed a significant change of flow conditions due to model compliance. Attenuation of the flow rate pulse was recorded between the inlet and the outlet of the both model. This attenuation was 51% for PVA-H model. Moreover, a time lag between outlet pressure and outlet flow rate curves was recorded in both model. This time lag was longer with the PVAH model, as this model exhibit a greater compliance. PIV experiments revealed significant changes of flow patterns and velocity inside the aneurysm. Because of its high compliance, PVA-H model walls moved under the pulsatile conditions. A change of flow direction and decrease of its velocity were observed near the proximal wall of the aneurysm, compared to the silicone model. Such differences might modify the stress on the wall of the aneurysm. To conclude, our experiments revealed that compliance has significant impacts on flow properties and should be taken into account for in vitro vascular model manufacturing.

Original languageEnglish
Title of host publicationBiomedical and Biotechnology Engineering
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791852026
DOIs
Publication statusPublished - 2018 Jan 1
EventASME 2018 International Mechanical Engineering Congress and Exposition, IMECE 2018 - Pittsburgh, United States
Duration: 2018 Nov 92018 Nov 15

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume3

Other

OtherASME 2018 International Mechanical Engineering Congress and Exposition, IMECE 2018
CountryUnited States
CityPittsburgh
Period18/11/918/11/15

ASJC Scopus subject areas

  • Mechanical Engineering

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  • Cite this

    Matsuura, M., Tupin, S., & Ohta, M. (2018). Compliance effect on the flow condition in vascular in vitro experiments. In Biomedical and Biotechnology Engineering (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 3). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE201887362